Abstract
A recent genomewide screen identified 13 transposable elements that are likely to have been adaptive during or after the spread of Drosophila melanogaster out of Africa. One of these insertions, Bari-Juvenile hormone epoxy hydrolase (Bari-Jheh), was associated with the selective sweep of its flanking neutral variation and with reduction of expression of one of its neighboring genes: Jheh3. Here, we provide further evidence that Bari-Jheh insertion is adaptive. We delimit the extent of the selective sweep and show that Bari-Jheh is the only mutation linked to the sweep. Bari-Jheh also lowers the expression of its other flanking gene, Jheh2. Subtle consequences of Bari-Jheh insertion on life-history traits are consistent with the effects of reduced expression of the Jheh genes. Finally, we analyze molecular evolution of Jheh genes in both the long- and the short-term and conclude that Bari-Jheh appears to be a very rare adaptive event in the history of these genes. We discuss the implications of these findings for the detection and understanding of adaptation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alleles
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Amino Acid Substitution / genetics
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Animals
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Base Pairing / genetics
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Base Sequence
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Cell Survival
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Conserved Sequence*
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DNA Transposable Elements / genetics*
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DNA, Intergenic / genetics
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / growth & development*
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Evolution, Molecular
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Gene Expression Regulation
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Genes, Insect
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Models, Genetic
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Molecular Sequence Data
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Mutagenesis, Insertional / genetics*
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Mutation / genetics
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Open Reading Frames / genetics
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Ovum / cytology
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Phenotype
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Polymorphism, Genetic
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Quantitative Trait Loci / genetics*
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Selection, Genetic
Substances
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DNA Transposable Elements
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DNA, Intergenic
Associated data
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GENBANK/GQ169144
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