Cytochrome P-450 polymorphisms and response to clopidogrel

N Engl J Med. 2009 May 21;360(21):2249-50; author reply 2251. doi: 10.1056/NEJMc090391.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Biotransformation
  • Clopidogrel
  • Cytochrome P-450 CYP2C19
  • Humans
  • Linkage Disequilibrium
  • Microsomes / metabolism
  • Omeprazole / metabolism
  • Platelet Aggregation Inhibitors / metabolism
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Polymorphism, Genetic*
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / metabolism
  • Ticlopidine / therapeutic use

Substances

  • Platelet Aggregation Inhibitors
  • 2-oxo-clopidogrel
  • Clopidogrel
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Omeprazole
  • Ticlopidine