Abstract
The development of glycan arrays has enabled the high-sensitivity and high-throughput analysis of carbohydrate-protein interactions and contributed to significant advances in glycomics. A number of new array platforms that allow for qualitative and quantitative analysis of mono- and multivalent interactions on surfaces have been developed recently. Glycan arrays are not only a powerful tool for basic research, but also a promising technique for medical diagnosis, and detection of pathogens and cancers. These studies also have led to the design of efficient carbohydrate-based antimicrobial or anticancer vaccines.
MeSH terms
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Animals
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Antibodies, Monoclonal / blood
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Antibodies, Monoclonal / immunology
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Antigens, Tumor-Associated, Carbohydrate / chemistry
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Antigens, Tumor-Associated, Carbohydrate / immunology
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Carbohydrate Sequence
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Communicable Diseases / diagnosis*
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Glycomics / instrumentation
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Glycomics / methods
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Glycomics / trends
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Glycoproteins / metabolism*
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Glycosaminoglycans / chemistry
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Glycosaminoglycans / metabolism
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Humans
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Microarray Analysis / instrumentation
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Microarray Analysis / methods*
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Microarray Analysis / trends
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Molecular Sequence Data
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Neoplasms / diagnosis*
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Polysaccharides / chemistry*
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Polysaccharides / metabolism*
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Protein Binding
Substances
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Antibodies, Monoclonal
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Antigens, Tumor-Associated, Carbohydrate
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Globo-H
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Glycoproteins
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Glycosaminoglycans
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Polysaccharides