Lobectomy with pulmonary artery resection: morbidity, mortality, and long-term survival

J Thorac Cardiovasc Surg. 2009 Jun;137(6):1400-5. doi: 10.1016/j.jtcvs.2008.11.002. Epub 2009 Feb 23.

Abstract

Objective: We report our experience with 93 consecutive pulmonary artery reconstructions during pulmonary lobectomy with regard to morbidity, mortality, and long-term survival.

Methods: Clinical records of all patients who underwent lobectomy with partial or circumferential pulmonary artery resection in a single institution during an 8-year period were reviewed retrospectively.

Results: Lobectomy with partial (n = 90) or circumferential (n = 3) pulmonary artery resection was carried out in 93 patients. Indications for surgical intervention were non-small cell lung cancer in 87 patients and other malignancy in the remaining 6 patients. Bronchial sleeve resection was associated in 23 patients. Neoadjuvant chemotherapy had been administered in 34 cases because of cN2 disease. Operative mortality was 5.4%. Postoperative complications occurred in 27 (29.0%) patients. All the patients underwent contrast-enhanced computed tomographic scanning 6 to 8 weeks postoperatively, which always showed patency of the pulmonary arteries. In the whole population median and 5-year survivals were 40 months and 39.4%, respectively. Disease-free survival was 41.4% at 5 years. Among patients with non-small cell lung cancer, at univariate analysis, tumor size of less than 3 cm; presence of vascular peritumoral emboli, intratumoral emboli, or both; and dyspnea influenced 5-year survival. Multivariate analysis showed that the size of the primary tumor and the presence of vascular emboli were independent factors of worse outcome.

Conclusions: Lobectomy with arterial sleeve resection has acceptable mortality and no specific complications. Late results in terms of survival are satisfactory.

MeSH terms

  • Adenocarcinoma / surgery
  • Aged
  • Carcinoma, Large Cell / surgery
  • Carcinoma, Non-Small-Cell Lung / surgery
  • Carcinoma, Squamous Cell / surgery
  • Disease-Free Survival
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / physiopathology
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Pneumonectomy* / methods
  • Postoperative Complications
  • Pulmonary Artery / surgery*
  • Survival Rate