Iron(III)-catalyzed and air-mediated tandem reaction of aldehydes, alkynes and amines: an efficient approach to substituted quinolines

Chemistry. 2009 Jun 22;15(26):6332-4. doi: 10.1002/chem.200900875.

Abstract

Economic and practical advantages are offered by the iron(III)-catalyzed and air-mediated tandem coupling/hydroarylation/dehydrogenation of simple readily available aldehydes, alkynes, and amines for the synthesis of 2, 4-disubstituted quinolines (see scheme).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Alkynes / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Ferric Compounds / chemistry*
  • Molecular Structure
  • Pargyline / analogs & derivatives
  • Pargyline / chemistry
  • Propylamines / chemistry
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry

Substances

  • Aldehydes
  • Alkynes
  • Amines
  • Ferric Compounds
  • Propylamines
  • Quinolines
  • propargylamine
  • Pargyline