Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population

M L Wang; J H Lai; Y Zhu; H B Zhang; C Li; J P Wang; Y M Li; A G Yang; B Q Jin

doi:10.1111/j.1744-313X.2009.00848.x

Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population

Int J Immunogenet. 2009 Aug;36(4):227-9. doi: 10.1111/j.1744-313X.2009.00848.x. Epub 2009 May 19.

Authors

M L Wang¹, J H Lai, Y Zhu, H B Zhang, C Li, J P Wang, Y M Li, A G Yang, B Q Jin

Affiliation

¹ Department of Immunology, Fourth Military Medical University, 17 Changle West Road, Xi'an, China.

PMID: 19473214
DOI: 10.1111/j.1744-313X.2009.00848.x

Abstract

We report a significantly higher occurrence of HLA-DRB1*09 (51% vs. 23%, P = 0.002, OR = 3.57) and HLA-B*46-DRB1*09 (26% vs. 8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus-induced HFRS is associated with a genetic predisposition in the Chinese Han population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Asian People / genetics
China / epidemiology
Gene Frequency
Genetic Predisposition to Disease*
Genotype
HLA-A Antigens / genetics*
HLA-B Antigens / genetics
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Hantaan virus*
Haplotypes / genetics
Hemorrhagic Fever with Renal Syndrome / epidemiology
Hemorrhagic Fever with Renal Syndrome / genetics*
Hemorrhagic Fever with Renal Syndrome / immunology*
Humans
Logistic Models
Retrospective Studies

Substances

HLA-A Antigens
HLA-B Antigens
HLA-DR Antigens
HLA-DRB1 Chains