Post-pneumonectomy bronchopleural fistulas (BPFs) still represent a formidable therapeutic challenge. Several procedures have been proposed of which the least invasive are gaining distinct recognition and favour. We report the case of small-sized BPF treated by plastering the bronchial stump with a combination of bone substitute composite sprayed on a scaffold made of a Vycril mesh and placed on the mediastinal pleura overlying the right hilum.