Abstract
Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.
MeSH terms
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Animals
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Female
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Humans
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Lung Neoplasms / secondary
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Lymphatic Metastasis
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Mammary Neoplasms, Experimental / metabolism*
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Mammary Neoplasms, Experimental / pathology
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Mice
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Mice, Transgenic
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Multienzyme Complexes / genetics
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Multienzyme Complexes / metabolism*
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Neoplasm Invasiveness
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Phosphodiesterase I / genetics
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Phosphodiesterase I / metabolism*
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Phosphoric Diester Hydrolases
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Pyrophosphatases / genetics
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Pyrophosphatases / metabolism*
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Receptors, Lysophosphatidic Acid / genetics
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Receptors, Lysophosphatidic Acid / physiology*
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Signal Transduction / physiology
Substances
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Multienzyme Complexes
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Receptors, Lysophosphatidic Acid
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Phosphoric Diester Hydrolases
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Phosphodiesterase I
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alkylglycerophosphoethanolamine phosphodiesterase
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Pyrophosphatases