TNF 308 G/A polymorphism and type 1 diabetes: a meta-analysis

Ren-Nan Feng; Ying Li; Chang-Hao Sun

doi:10.1016/j.diabres.2009.04.026

TNF 308 G/A polymorphism and type 1 diabetes: a meta-analysis

Diabetes Res Clin Pract. 2009 Jul;85(1):e4-7. doi: 10.1016/j.diabres.2009.04.026. Epub 2009 May 27.

Authors

Ren-Nan Feng¹, Ying Li, Chang-Hao Sun

Affiliation

¹ Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin 150086, China.

PMID: 19477545
DOI: 10.1016/j.diabres.2009.04.026

Abstract

We conducted a meta-analysis to examine the association between TNF 308 G/A polymorphism and risk for T1DM. Eleven reports were identified. Our study confirmed that a higher frequency of TNF 308 A allele conferred a significant risk for T1DM. Potential explanations were discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / genetics*
Diabetes Mellitus, Type 1 / immunology
Humans
Meta-Analysis as Topic
Polymorphism, Genetic*
Promoter Regions, Genetic
Risk Factors
Tumor Necrosis Factor-alpha / genetics*

Substances

Tumor Necrosis Factor-alpha