Abstract
Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Communication / physiology
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Cell Differentiation / physiology
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Cell Movement / physiology
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Chick Embryo
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Collagen / metabolism*
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Discoidin Domain Receptors
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Endocardial Cushions / cytology
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Endocardial Cushions / embryology
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Endocardial Cushions / metabolism
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Endocardium / cytology
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Endocardium / embryology
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Endocardium / metabolism
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Endothelial Cells / cytology
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Endothelial Cells / metabolism
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Fibroblasts / cytology
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Fibroblasts / metabolism
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Gene Expression Regulation, Developmental / physiology
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Heart / embryology*
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Heart Atria / cytology
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Heart Atria / embryology
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Heart Atria / metabolism
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Heart Ventricles / cytology
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Heart Ventricles / metabolism
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Mesoderm / cytology
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Mesoderm / embryology*
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Mesoderm / metabolism*
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Myocardium / cytology
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Myocardium / metabolism
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Organogenesis / physiology*
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / metabolism*
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Receptors, Collagen / genetics
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Receptors, Collagen / metabolism*
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Receptors, Mitogen / genetics
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Receptors, Mitogen / metabolism*
Substances
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Receptors, Collagen
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Receptors, Mitogen
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Collagen
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Discoidin Domain Receptors
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Receptor Protein-Tyrosine Kinases