High frequency of antiretroviral drug resistance among HIV-infected adults receiving first-line highly active antiretroviral therapy in N'Djamena, Chad

Clin Infect Dis. 2009 Jul 1;49(1):155-9. doi: 10.1086/599611.

Abstract

Antiretroviral drug resistance was evaluated in 88 adults infected with human immunodeficiency virus, most with subtype CRF11_cpx, who had received a first-line antiretroviral regimen for 6 months, in N'Djamena, Chad. A total of 47 patients (53%) had detectable viral load at month 6, and 56 (64%) had at least 1 antiretroviral resistance mutation observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active*
  • Chad
  • Drug Resistance, Viral*
  • HIV Infections / drug therapy*
  • HIV Infections / virology*
  • HIV-1 / drug effects*
  • HIV-1 / isolation & purification
  • Humans
  • Molecular Sequence Data
  • Mutation, Missense
  • RNA, Viral / genetics
  • Sequence Analysis, DNA
  • Young Adult

Substances

  • Anti-HIV Agents
  • RNA, Viral

Associated data

  • GENBANK/FJ688173
  • GENBANK/FJ688174
  • GENBANK/FJ688175
  • GENBANK/FJ688176
  • GENBANK/FJ688177
  • GENBANK/FJ688178
  • GENBANK/FJ688179
  • GENBANK/FJ688180
  • GENBANK/FJ688181
  • GENBANK/FJ688182
  • GENBANK/FJ688183
  • GENBANK/FJ688184
  • GENBANK/FJ688185
  • GENBANK/FJ688186
  • GENBANK/FJ688187
  • GENBANK/FJ688188
  • GENBANK/FJ688189
  • GENBANK/FJ688190
  • GENBANK/FJ688191
  • GENBANK/FJ688192
  • GENBANK/FJ688193
  • GENBANK/FJ688194
  • GENBANK/FJ688195
  • GENBANK/FJ688196
  • GENBANK/FJ688197
  • GENBANK/FJ688198
  • GENBANK/FJ688199
  • GENBANK/FJ688200
  • GENBANK/FJ688201
  • GENBANK/FJ688202
  • GENBANK/FJ688203
  • GENBANK/FJ688204
  • GENBANK/FJ688205
  • GENBANK/FJ688206
  • GENBANK/FJ688207
  • GENBANK/FJ688208
  • GENBANK/FJ688209