Coccidioides immitis meningitis in a patient with hyperimmunoglobulin E syndrome due to a novel mutation in signal transducer and activator of transcription

Pediatr Infect Dis J. 2009 Jul;28(7):664-6. doi: 10.1097/INF.0b013e31819866ec.

Abstract

Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency characterized by recurrent skin and lung infections. We report the first case of Coccidioides immitis meningitis in a patient with HIES. Coccidioides should be included in the differential diagnosis for central nervous system infections in HIES patients.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Amino Acid Substitution / genetics
  • Amphotericin B / therapeutic use
  • Antibodies, Fungal / cerebrospinal fluid
  • Antifungal Agents / therapeutic use
  • Cerebrospinal Fluid / microbiology
  • Coccidioides / isolation & purification*
  • Coccidioidomycosis / diagnosis*
  • Coccidioidomycosis / drug therapy
  • Coccidioidomycosis / microbiology
  • Coccidioidomycosis / pathology
  • Exons / genetics
  • Female
  • Humans
  • Immunoglobulin G / cerebrospinal fluid
  • Job Syndrome / complications*
  • Job Syndrome / diagnosis*
  • Job Syndrome / drug therapy
  • Job Syndrome / pathology
  • Meningitis, Fungal / diagnosis*
  • Meningitis, Fungal / drug therapy
  • Meningitis, Fungal / microbiology
  • Meningitis, Fungal / pathology
  • Mutation, Missense*
  • STAT3 Transcription Factor / genetics*
  • Sequence Analysis, DNA

Substances

  • Antibodies, Fungal
  • Antifungal Agents
  • Immunoglobulin G
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Amphotericin B