Abstract
Retrospective testing of neonatal Guthrie card blood spots for specific immunoglobulin M (IgM) can distinguish congenital toxoplasmosis from acquired toxoplasmosis. We determined whether storage temperature reduced IgM detection, using filter paper blood samples "spiked" with anti-Toxoplasma IgM. After 300 days, IgM detection deteriorated with storage at room temperature but not at temperatures of 4 degrees C or lower.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Animals
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Antibodies, Bacterial / immunology*
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Blood / immunology*
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Child
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Child, Preschool
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Desiccation
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Humans
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Immunoglobulin M / immunology*
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Infant
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Infant, Newborn
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Refrigeration
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Specimen Handling / methods*
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Temperature
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Time Factors
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Toxoplasma / immunology*
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Toxoplasmosis / diagnosis*
Substances
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Antibodies, Bacterial
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Immunoglobulin M