Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii

Phytother Res. 2010 May;24(5):775-7. doi: 10.1002/ptr.2894.

Abstract

The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and beta-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology*
  • Dioxoles
  • Furans / isolation & purification
  • Furans / pharmacology
  • Molecular Structure
  • Plant Bark / chemistry
  • Plant Extracts / pharmacology
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / growth & development
  • Quinolines / isolation & purification
  • Quinolines / pharmacology*
  • Rutaceae / chemistry*

Substances

  • Alkaloids
  • Antimalarials
  • Dioxoles
  • Furans
  • Plant Extracts
  • Quinolines
  • maculine
  • montrifoline
  • tecleaverdoornine
  • kokusaginine