Structural features of the Zn(2+) complex with the single repeat region of "prion related protein" (PrP-rel-2) of zebrafish zPrP63-70 fragment

Francesca Camponeschi; Elena Gaggelli; Henryk Kozłowski; Daniela Valensin; Gianni Valensin

doi:10.1039/b907626n

Structural features of the Zn(2+) complex with the single repeat region of "prion related protein" (PrP-rel-2) of zebrafish zPrP63-70 fragment

Dalton Trans. 2009 Jun 28:(24):4643-5. doi: 10.1039/b907626n. Epub 2009 Apr 30.

Authors

Francesca Camponeschi¹, Elena Gaggelli, Henryk Kozłowski, Daniela Valensin, Gianni Valensin

Affiliation

¹ Department of Chemistry, University of Siena, via Aldo Moro, 53100, Siena, Italy.

PMID: 19513471
DOI: 10.1039/b907626n

Abstract

The interaction between Zn(2+) and the single repeat of PrP-rel-2 of zebrafish at physiological pH was investigated by NMR spectroscopy; the chemical shift mapping and the proton-proton distances were used to obtain the structural model of the Zn(2+) complex.

MeSH terms

Animals
Binding Sites
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
Peptide Fragments / chemistry*
Peptide Fragments / metabolism
PrPC Proteins / chemistry*
PrPC Proteins / metabolism
Protein Binding
Protein Conformation
Zebrafish Proteins / chemistry*
Zebrafish Proteins / metabolism
Zebrafish*
Zinc / chemistry*
Zinc / metabolism

Substances

Peptide Fragments
PrPC Proteins
Zebrafish Proteins
prnpa protein, zebrafish
Zinc