Disappearance of vaccine-type invasive pneumococcal disease and emergence of serotype 19A in a minority population with a high prevalence of human immunodeficiency virus and low childhood immunization rates

Azadeh Tasslimi; Erica J Sison; Elizabeth Story; David Alland; Michele Burday; Susan Morrison; Sandhya Nalmas; Stephen Smith; Pauline A Thomas; Peter Wenger; Anushua Sinha

doi:10.1128/CVI.00140-09

Disappearance of vaccine-type invasive pneumococcal disease and emergence of serotype 19A in a minority population with a high prevalence of human immunodeficiency virus and low childhood immunization rates

Clin Vaccine Immunol. 2009 Aug;16(8):1256-9. doi: 10.1128/CVI.00140-09. Epub 2009 Jun 10.

Authors

Azadeh Tasslimi¹, Erica J Sison, Elizabeth Story, David Alland, Michele Burday, Susan Morrison, Sandhya Nalmas, Stephen Smith, Pauline A Thomas, Peter Wenger, Anushua Sinha

Affiliation

¹ Department of Preventive Medicine and Community Health, New Jersey Medical School-UMDNJ, MSB F594, Newark, NJ 07103, USA.

Abstract

We analyzed the epidemiology of invasive pneumococcal disease (IPD) following introduction of pneumococcal conjugated vaccine in an urban population with a 2% human immunodeficiency virus (HIV) prevalence and history of low childhood immunization rates. We observed near-elimination of vaccine-type IPD. Substantial disease remains due to non-vaccine-type pneumococci, highlighting the need to increase pneumococcal immunization among HIV-infected adults.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Female
HIV Infections / complications*
Humans
Infant
Male
Middle Aged
Pneumococcal Infections / epidemiology*
Pneumococcal Infections / microbiology*
Pneumococcal Vaccines / immunology*
Prevalence
Serotyping
Streptococcus pneumoniae / classification*
Streptococcus pneumoniae / immunology
Streptococcus pneumoniae / isolation & purification*
United States
Urban Population
Young Adult

Substances

Pneumococcal Vaccines