Recent advances in synthesis of PAR ligands as therapeutic strategy for inflammatory diseases

B Severino; V Santagada; E Perissutti; F Fiorino; F Frecentese; F De Angelis; A Esposito; G Caliendo

doi:10.2174/138955709788452711

Recent advances in synthesis of PAR ligands as therapeutic strategy for inflammatory diseases

Mini Rev Med Chem. 2009 Jun;9(6):653-63. doi: 10.2174/138955709788452711.

Authors

B Severino¹, V Santagada, E Perissutti, F Fiorino, F Frecentese, F De Angelis, A Esposito, G Caliendo

Affiliation

¹ Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, via D. Montesano 49, -80131 Naples, Italy.

PMID: 19519491
DOI: 10.2174/138955709788452711

Abstract

Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.

Publication types

Review

MeSH terms

Animals
Biomimetic Materials / chemical synthesis
Biomimetic Materials / chemistry
Biomimetic Materials / pharmacology
Biomimetic Materials / therapeutic use
Heterocyclic Compounds / chemical synthesis
Heterocyclic Compounds / chemistry
Heterocyclic Compounds / pharmacology
Heterocyclic Compounds / therapeutic use
Humans
Inflammation / drug therapy*
Inflammation / metabolism*
Ligands
Organic Chemicals / chemical synthesis*
Organic Chemicals / chemistry
Organic Chemicals / pharmacology*
Organic Chemicals / therapeutic use
Receptors, Proteinase-Activated / agonists*
Receptors, Proteinase-Activated / antagonists & inhibitors*
Receptors, Proteinase-Activated / metabolism

Substances

Heterocyclic Compounds
Ligands
Organic Chemicals
Receptors, Proteinase-Activated