Transesophageal Doppler (TED) monitoring provides continuous, noninvasive monitoring of cardiac output by measurement of aortic flow velocities. Because of the effects on aortic flow dynamics resulting from atherosclerosis, aortic cross-clamping, and wide variations in arterial blood pressure, the validity of TED monitoring during aortic surgery is unresolved. The authors prospectively evaluated a second-generation TED cardiac output monitor in 42 patients undergoing aortic reconstructive surgery. Four hundred eighty-nine simultaneous measurements of TED and thermodilution cardiac output were obtained. Transesophageal Doppler measurements were highly correlated to thermodilution measurements (R = 0.94); however, Bland-Altman analysis revealed a moderate error in the TED measurements (2 SD of the bias = 1.4 L/min). Trending analysis showed that TED monitoring accurately tracked changes in thermodilution cardiac output. Placement of an aortic cross-clamp resulted in significant reductions in the accuracy of Doppler measurements. Arterial blood pressure variations did not systematically affect the accuracy of the transesophageal technique. Limitations of TED monitoring, including a difficult calibration procedure, poor performance during aortic cross-clamping, and the need for probe repositioning, suggest further development is warranted.