Abstract
We have previously shown that modification of polyphenols with a ferrocenyl group can dramatically enhance their cytotoxicity. We now present two new [3]ferrocenophane compounds, one of which has an antiproliferative effect seven times stronger than the corresponding noncyclic species, with IC50 values of 90 and 94 nM on hormone-independent MDA-MB-231 breast and PC-3 prostate cancer cell lines, respectively. Solubility studies in water using methylated beta-cyclodextrin and electron transfer studies are also presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Cell Line, Tumor
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Female
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Flavonoids / chemical synthesis*
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Flavonoids / pharmacology
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Humans
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Male
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Phenols / chemical synthesis*
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Phenols / pharmacology
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Polyphenols
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / pathology
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Structure-Activity Relationship
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beta-Cyclodextrins / pharmacology
Substances
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Antineoplastic Agents
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Flavonoids
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Phenols
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Polyphenols
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beta-Cyclodextrins
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betadex