Bacterial type III effectors inhibit cell lifting by targeting integrin-linked kinase

Cell Host Microbe. 2009 Jun 18;5(6):514-6. doi: 10.1016/j.chom.2009.06.001.

Abstract

Many pathogenic bacteria are able to surmount exfoliation and colonize the host epithelium efficiently. In a recent article in Nature, Kim et al. (2009) show that Shigella flexneri OspE, a conserved type III effector, reinforces host cell adherence and prevents detachment of the infected cells by interacting with integrin-linked kinase.

Publication types

  • Review

MeSH terms

  • Bacteria / pathogenicity*
  • Bacterial Proteins / metabolism*
  • Carrier Proteins / metabolism*
  • Host-Pathogen Interactions
  • Models, Biological
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*
  • Shigella flexneri / pathogenicity
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Carrier Proteins
  • Virulence Factors
  • integrin-linked kinase
  • Protein Serine-Threonine Kinases