Early malignant transformation of a petroclival meningothelial meningioma

Neurosurg Rev. 2009 Oct;32(4):495-9. doi: 10.1007/s10143-009-0207-3. Epub 2009 Jun 17.

Abstract

Although some authors have reported the malignant transformation of meningiomas, there has been no previous report describing that a meningothelial meningioma transformed into an atypical meningioma within 1 year. This report documents a 57-year-old woman who presented with right hearing disturbance. Magnetic resonance imaging revealed a right petroclival meningioma. The tumor was subtotally removed and was diagnosed to be a meningothelial meningioma. Seven months after surgery, a recurrence of the tumor was confirmed. The diagnosis of this recurrent tumor was an atypical meningioma. The MIB-1 index and the percent of p53 protein-positive cells in the primary tumor were 4.6% and 35.4%, respectively, whereas those of the recurrent tumor were 34.7% and 33.1%, respectively. A chromosomal DNA copy number loss was observed on 1p, 6q, 10, 14q, and -22q detected in both the primary and the recurrent tumors. These results suggest that the present case had a potentially malignant tumor in the early stage, although it had the histological features of benign meningiomas. An evaluation of the MIB-1 index, as well as the expression of p53 and chromosomal aberrations, may be useful for predicting the malignant transformation of meningiomas.

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic
  • Cerebral Angiography
  • DNA / genetics
  • Female
  • Gait Disorders, Neurologic
  • Gene Dosage
  • Hearing Disorders / etiology
  • Humans
  • Ki-67 Antigen / analysis
  • Magnetic Resonance Imaging
  • Meningeal Arteries / surgery
  • Meningeal Neoplasms / genetics
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / surgery
  • Meningioma / genetics
  • Meningioma / pathology*
  • Meningioma / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neurosurgical Procedures
  • Tumor Suppressor Protein p53 / genetics

Substances

  • Ki-67 Antigen
  • Tumor Suppressor Protein p53
  • DNA