Abstract
Beclin 1 binds to Bcl-2 through its BH3 domain and this interaction inhibits starvation-induced autophagy. However, we have found that when Beclin 1 binds thus to Bcl-2, it fails to inhibit Bcl-2-mediated protection against four different inducers of apoptosis. In this punctum, we discuss possible reasons why Beclin 1 fails to behave like other BH3-only proteins and induce apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis Regulatory Proteins / metabolism*
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Apoptosis*
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Autophagy
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Beclin-1
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HeLa Cells
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Humans
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Membrane Proteins / metabolism*
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Mice
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Models, Biological
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Proto-Oncogene Proteins c-bcl-2 / metabolism*
Substances
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Apoptosis Regulatory Proteins
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BECN1 protein, human
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Beclin-1
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Membrane Proteins
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Proto-Oncogene Proteins c-bcl-2