Abstract
The receptor for the lipid mediator sphingosine 1-phosphate is critical for T cell trafficking. New data show that signaling mediated by this receptor critically controls the development, maintenance and suppressive activity of natural regulatory T cells that express the transcription factor Foxp3.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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Carrier Proteins / metabolism
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Cell Differentiation / immunology
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Forkhead Transcription Factors / metabolism
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Mice
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Models, Biological
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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Receptors, Lysosphingolipid / metabolism*
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Signal Transduction / immunology
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
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TOR Serine-Threonine Kinases
Substances
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Carrier Proteins
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Forkhead Transcription Factors
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Foxp3 protein, mouse
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Receptors, Lysosphingolipid
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Phosphotransferases (Alcohol Group Acceptor)
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mTOR protein, mouse
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Proto-Oncogene Proteins c-akt
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TOR Serine-Threonine Kinases