Abstract
The synthesis of some 5-hydroxy-4-imino-2,3-dihydrobenzopyran derivatives of GABA and alkylamines is described. The products were tested for their GABA-receptor binding and anticonvulsant activity in mice. Some compounds showed anticonvulsant activity. No binding to GABA receptors was observed.
MeSH terms
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3-Mercaptopropionic Acid / antagonists & inhibitors
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / pharmacology
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Bicuculline / antagonists & inhibitors
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Chromans / chemical synthesis*
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Chromans / pharmacology
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Imines / chemical synthesis*
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Imines / pharmacology
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Male
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Mice
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Mice, Inbred ICR
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Mice, Inbred Strains
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Pentylenetetrazole / antagonists & inhibitors
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Picrotoxin / antagonists & inhibitors
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Rats
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / chemical synthesis
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gamma-Aminobutyric Acid / pharmacology*
Substances
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Anticonvulsants
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Chromans
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Imines
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Picrotoxin
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gamma-Aminobutyric Acid
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3-Mercaptopropionic Acid
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Pentylenetetrazole
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Bicuculline