Abstract
The synthesis of N-salicyloyl-N-benzyl-thiourea and 2,2-dimethyl-4-oxo-6-methoxy-benzo-1,3-dioxin are described. They were studied for their antiviral, antiproliferative and antimicrobial activities in vitro. N-salicyloyl-N-benzyl-thiourea exhibited significant activity against Gram-positive bacteria and against influenza viruses types A/Philippine/H3N2, A/Chilli/H1N1 and B/Paraha, as well as against K562 cell proliferation. By contrast, no such activity was demonstrated by 2,2-dimethyl-4-oxo-6-methoxy-benzo-1,3-dioxin.
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Antiviral Agents / chemical synthesis
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Cell Division / drug effects
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Cell Survival / drug effects
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Dioxins / chemical synthesis*
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Dioxins / pharmacology
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Salicylates / chemical synthesis*
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Salicylates / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
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Viral Plaque Assay
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Viruses / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antiviral Agents
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Dioxins
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Salicylates
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N-salicyloyl-N-benzylthiourea
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2,2-dimethyl-4-oxo-6-methoxybenzo-1,3-dioxin