Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease

Xiaoqiang Chen; Jiangli Fan; Xiaojun Peng; Jingyun Wang; Shiguo Sun; Rong Zhang; Tong Wu; Fei Zhang; Jianfeng Liu; Fen Wang; Saijian Ma

doi:10.1016/j.bmcl.2009.06.003

Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4139-42. doi: 10.1016/j.bmcl.2009.06.003. Epub 2009 Jun 6.

Authors

Xiaoqiang Chen¹, Jiangli Fan, Xiaojun Peng, Jingyun Wang, Shiguo Sun, Rong Zhang, Tong Wu, Fei Zhang, Jianfeng Liu, Fen Wang, Saijian Ma

Affiliation

¹ State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China.

PMID: 19539469
DOI: 10.1016/j.bmcl.2009.06.003

Abstract

Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acridines / chemistry*
Catalysis
Chemistry / methods
Chemistry, Pharmaceutical / methods
DNA / chemistry
Deoxyribonucleases / chemistry*
Drug Design
Electrophoresis, Agar Gel / methods
Hydrolysis
Intercalating Agents / pharmacology
Iron / chemistry*
Kinetics
Models, Chemical
Plasmids / metabolism

Substances

Acridines
Intercalating Agents
DNA
Iron
Deoxyribonucleases