Nodular amyloidosis: differentiation from colloid milium by electron microscopy

Am J Dermatopathol. 2009 Jul;31(5):472-4. doi: 10.1097/DAD.0b013e31818c5cd3.

Abstract

Nodular amyloidosis is a primary cutaneous amyloidosis characterized by the deposition of amyloid L-type fibril proteins in the dermis. Clinical history and routine histology may not be sufficient to differentiate nodular amyloidosis from colloid milium. We present a case of a 45-year-old man with nodular amyloidosis, whose diagnosis was confirmed by the characteristic appearance of filaments on electron microscopy.

Publication types

  • Case Reports

MeSH terms

  • Acne Vulgaris / complications
  • Acne Vulgaris / drug therapy
  • Amyloidosis / complications
  • Amyloidosis / pathology*
  • Dermatologic Agents / therapeutic use
  • Diagnosis, Differential
  • Face / pathology
  • Facial Dermatoses / pathology
  • Humans
  • Isotretinoin / therapeutic use
  • Male
  • Microscopy, Electron, Transmission
  • Middle Aged
  • Skin Diseases / complications
  • Skin Diseases / pathology*

Substances

  • Dermatologic Agents
  • Isotretinoin