Interaction of indoleamine-2,3-dioxyagnase and CD4+CD25+ regulatory T cells in tumor immune escape

Hui Wang; Ke Pan; Jian-Chuan Xia

Interaction of indoleamine-2,3-dioxyagnase and CD4+CD25+ regulatory T cells in tumor immune escape

Ai Zheng. 2009 Feb;28(2):184-7. Epub 2009 Feb 12.

Authors

Hui Wang¹, Ke Pan, Jian-Chuan Xia

Affiliation

¹ State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.

PMID: 19550135

Abstract

There are numerous factors involved in the tumor evasion from immune surveillance. Recently, considerable attention has been given to indoleamine 2,3-dioxygenase (IDO) and CD4(+)CD25(+) regulatory T cells (Tregs). The interaction between the two may play a crucial role in tumor immune escape. This article reviews the correlation between IDO and Tregs in immune escape of tumors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism*
Interleukin-2 Receptor alpha Subunit / immunology
Models, Biological
Protein Binding
Protein Serine-Threonine Kinases / metabolism
Signal Transduction / immunology
T-Lymphocytes, Regulatory / immunology*
T-Lymphocytes, Regulatory / metabolism
Tumor Escape / immunology*

Substances

Indoleamine-Pyrrole 2,3,-Dioxygenase
Interleukin-2 Receptor alpha Subunit
EIF2AK4 protein, human
Protein Serine-Threonine Kinases