Abstract
Invasive fungal sinusitis is a relatively rare disease and can be divided into acute fulminant, chronic, and granulomatous invasive fungal sinusitis. The conventional treatment is radical surgery combined with systemic amphotericin B administration, but the poor prognosis and unestablished treatment options require a better therapeutic strategy. We report three cases of chronic invasive fungal sinusitis successfully treated with a combination of surgery and voriconazole, a new antifungal agent, with good responses in all patients. Voriconazole administration could form the basis for a new standard treatment for invasive fungal sinusitis.
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
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Aged
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Aged, 80 and over
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Antifungal Agents / adverse effects
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Antifungal Agents / therapeutic use*
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Aspergillosis / drug therapy*
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Aspergillosis / surgery*
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Combined Modality Therapy
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Follow-Up Studies
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Humans
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Magnetic Resonance Imaging
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Male
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Maxillary Sinusitis / diagnosis
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Maxillary Sinusitis / drug therapy*
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Maxillary Sinusitis / surgery*
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Pyrimidines / adverse effects
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Pyrimidines / therapeutic use*
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Sphenoid Sinusitis / diagnosis
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Sphenoid Sinusitis / drug therapy*
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Sphenoid Sinusitis / surgery*
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Tomography, X-Ray Computed
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Triazoles / adverse effects
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Triazoles / therapeutic use*
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Voriconazole