Abstract
We report a 65-year-old male with hepatitis C virus (HCV)-associated glomerulonephritis (GN) and AL amyloidosis. This patient had a 14-year history of HCV infection with positive serum HCV RNA at presentation. Diagnosis of HCV-related GN was established using immunohistochemistry in which the HCV-NS3 antigen was mainly detected as granular deposition in glomerular mesangium. AL amyloidosis was determined by electron microscopy, positive Congo red staining and identification of lambda-chain in the kidney specimen and monoclonal IgG-lambda in serum and urine. Under immunoelectron microscopy, the HCV-NS3 antigen was found in electron-dense deposits, while lambda-chains appeared in the amyloid-like filaments.
MeSH terms
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Aged
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Amyloid / metabolism
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Amyloidosis / complications*
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Amyloidosis / immunology
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Amyloidosis / metabolism
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Amyloidosis / pathology
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Glomerulonephritis / complications*
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Glomerulonephritis / etiology
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Glomerulonephritis / pathology
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Glomerulonephritis / virology
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Hepacivirus / metabolism
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Hepacivirus / pathogenicity
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Hepatitis C, Chronic / complications*
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Humans
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Immunohistochemistry
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Kidney / metabolism
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Kidney / pathology
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Kidney / virology
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Kidney Diseases / complications*
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Kidney Diseases / immunology
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Kidney Diseases / metabolism
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Kidney Diseases / pathology
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Male
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Microscopy, Immunoelectron
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Viral Nonstructural Proteins / metabolism
Substances
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Amyloid
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NS3 protein, hepatitis C virus
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Viral Nonstructural Proteins
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amyloid L, human