Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine

Chem Commun (Camb). 2009 Jul 7:(25):3714-6. doi: 10.1039/b908004j. Epub 2009 May 27.

Abstract

Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cysteine on protein surfaces, a useful transformation for the exploration of olefin metathesis on proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Allyl Compounds / chemistry
  • Bacillus / enzymology
  • Cysteine / analogs & derivatives*
  • Cysteine / chemistry
  • Models, Molecular
  • Protein Conformation
  • Proteins / chemistry*
  • Substrate Specificity
  • Subtilisin / chemistry
  • Sulfides / chemistry

Substances

  • Alkenes
  • Allyl Compounds
  • Proteins
  • Sulfides
  • S-allylcysteine
  • Subtilisin
  • Cysteine
  • allyl chloride