Abstract
Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amides / chemical synthesis
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Amides / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Brain Neoplasms / drug therapy*
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Cell Line, Tumor
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Chemistry, Pharmaceutical / methods*
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DNA / chemistry
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Dimerization
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Drug Screening Assays, Antitumor
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Glioma / drug therapy*
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Humans
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Hydrogen-Ion Concentration
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Models, Chemical
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Molecular Conformation
Substances
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Amides
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Antineoplastic Agents
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DNA