Abstract
Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster.
Publication types
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Clinical Trial, Phase I
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Clinical Trial, Phase II
MeSH terms
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Antibodies, Viral / blood
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Chickenpox Vaccine / adverse effects*
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Chickenpox Vaccine / immunology*
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Child
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HIV Infections / immunology*
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Herpes Zoster / prevention & control*
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Herpesvirus 3, Human / immunology*
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Humans
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Immunization, Secondary / methods*
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Longitudinal Studies
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Male
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T-Lymphocytes / immunology
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Vaccines, Attenuated / adverse effects
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Vaccines, Attenuated / immunology
Substances
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Antibodies, Viral
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Chickenpox Vaccine
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Vaccines, Attenuated