Oral eruption cysts develop when extravasated fluid, epithelial remnants of tooth embryogenesis, and blood obliterates the submucosal space encapsulating an erupting primary or permanent tooth. In immunocompetent children, these lesions are treated conservatively with watchful monitoring for spontaneous rupture, mucosal healing, and timely tooth emergence. We describe the clinical course for 2 oral eruption cysts in a child with Stage III hepatoblastoma treated with chemotherapy before liver transplant. This article provides recommendations for care when prophylactic surgical excision of oral eruption cysts is indicated in pediatric oncology patients.