Abstract
Treatment of omega-epoxynitriles with hydroxylamine affords cyclic aminonitrones in a single step and with high stereoselectivity. The scope of this novel transformation was explored in a series of examples. The aminonitrone products were shown to be useful substrates for further selective elaboration.
MeSH terms
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Crystallography, X-Ray
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Cyclization
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Drug Design
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HIV Integrase Inhibitors / chemical synthesis
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HIV Integrase Inhibitors / chemistry*
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Molecular Structure
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Pyrimidinones / chemical synthesis
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Pyrimidinones / chemistry*
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Pyrrolidinones / chemistry
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Raltegravir Potassium
Substances
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HIV Integrase Inhibitors
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Pyrimidinones
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Pyrrolidinones
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Raltegravir Potassium