Abstract
Meticillin-resistant Staphylococcus aureus (MRSA) strains harbouring staphylococcal cassette chromosome mec (SCCmec) type IVA are known to be more prevalent in South Korea than in other countries. Variations in the SCCmec IVA structure have been identified, including in sequence type (ST) 1 and ST72 strains. This study compared and investigated the genetic characteristics of two subtypes common in South Korea. Type IVA SCCmec of ST1 strains was characterized by type IV features with the linearized pUB110 at the junkyard (J) 3 region. However, that of ST72 strains carried a variant class B mec complex, ccrA2, with an identity of approximately 96 % and the linearized pUB110 at the J3 region. In SCCmec of ST72 strains, the organization of the class B variant and the J3 region may be more similar to that of type IA than to other types, but the ccr type and other J regions seemed to be derived from type IV. These genetic characteristics showed that type IVA appears to result from the dynamic genetic exchange and recombination of SCC DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Base Sequence
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Chromosomes, Bacterial / genetics
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Community-Acquired Infections / drug therapy*
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Community-Acquired Infections / epidemiology
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Community-Acquired Infections / microbiology*
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DNA Primers / genetics
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DNA, Bacterial / genetics
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Genetic Variation
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Humans
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Korea / epidemiology
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Methicillin Resistance / genetics*
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Methicillin-Resistant Staphylococcus aureus / genetics*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Methicillin-Resistant Staphylococcus aureus / pathogenicity
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Molecular Epidemiology
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Molecular Sequence Data
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Penicillin-Binding Proteins
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Phylogeny
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Recombination, Genetic
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Sequence Homology, Nucleic Acid
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / epidemiology
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Staphylococcal Infections / microbiology*
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Virulence / genetics
Substances
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Bacterial Proteins
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DNA Primers
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DNA, Bacterial
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Penicillin-Binding Proteins
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mecA protein, Staphylococcus aureus
Associated data
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GENBANK/EU437549
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GENBANK/EU437550