Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)

Phytomedicine. 2010 Mar;17(3-4):289-91. doi: 10.1016/j.phymed.2009.05.008. Epub 2009 Jul 2.

Abstract

Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Carbolines / isolation & purification
  • Carbolines / pharmacology*
  • Corpus Striatum / drug effects*
  • Corpus Striatum / metabolism
  • Dopamine / metabolism*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Homovanillic Acid / metabolism
  • Injections, Intraperitoneal
  • Male
  • Neurotransmitter Agents / administration & dosage
  • Neurotransmitter Agents / isolation & purification
  • Neurotransmitter Agents / pharmacology*
  • Phenylacetates / metabolism
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Rats
  • Rats, Wistar
  • Rubiaceae / chemistry*
  • Serotonin / analogs & derivatives
  • Serotonin / metabolism*

Substances

  • Carbolines
  • Glycosides
  • Neurotransmitter Agents
  • Phenylacetates
  • Plant Extracts
  • strictosidinic acid
  • 3,4-Dihydroxyphenylacetic Acid
  • Serotonin
  • Dopamine
  • Homovanillic Acid