Abstract
YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Bacterial Proteins / pharmacology*
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Bacterial Toxins / chemistry
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Bacterial Toxins / genetics
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Bacterial Toxins / metabolism
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Bacterial Toxins / pharmacology*
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Escherichia coli Proteins / chemistry
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Humans
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Molecular Sequence Data
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Peptide Chain Initiation, Translational / drug effects*
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Peptide Chain Initiation, Translational / physiology
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Protein Synthesis Inhibitors / chemistry
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Protein Synthesis Inhibitors / metabolism
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Protein Synthesis Inhibitors / pharmacology*
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Sequence Alignment
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Sequence Homology, Amino Acid*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / metabolism*
Substances
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Bacterial Proteins
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Bacterial Toxins
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Escherichia coli Proteins
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Protein Synthesis Inhibitors
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YefM protein, E coli
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YoeB protein, E coli