A new route to acyclic diaminocarbenes via lithium-halogen exchange

Org Lett. 2009 Aug 6;11(15):3274-7. doi: 10.1021/ol9013156.

Abstract

A lithium-halogen exchange route has been developed to generate acyclic diaminocarbenes (ADC) from chloroamidinium salts. Convenient access to various ADC complexes (B, Rh, Ir, Pd) stems from a one-pot transmetalation protocol. Formation of a carbenoid species is suggested by 1D and 2D NMR studies with a (13)C-labeled chloroamidinium precursor and also by X-ray structures of transition metal-carbene complexes. Rh-ADC complex 4 is an effective catalyst for the 1,2-addition of aryl boronic acids to aryl aldehydes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis*
  • Catalysis
  • Dioxolanes / chemical synthesis*
  • Halogens / chemistry*
  • Lithium / chemistry*

Substances

  • Alkynes
  • Dioxolanes
  • Halogens
  • aminocarbene
  • Lithium