Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn

J Agric Food Chem. 2009 Aug 12;57(15):6590-5. doi: 10.1021/jf901632j.

Abstract

To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for their inhibitory activities against tobacco mosaic virus (TMV). The activity of each compound against TMV infection and replication was tested using a half-leaf assay method, a leaf-disk method, and Western blotting analyses. All of the beta-carboline alkaloids showed moderate anti-TMV activities and exhibited synergistic effects when combined with the quassinoid nigakilactone B (11). To our knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.

MeSH terms

  • Alkaloids / pharmacology*
  • Antiviral Agents / pharmacology*
  • Carbolines / pharmacology*
  • Picrasma / chemistry*
  • Plant Extracts / pharmacology*
  • Tobacco Mosaic Virus / drug effects*
  • Tobacco Mosaic Virus / physiology
  • Virus Replication / drug effects

Substances

  • Alkaloids
  • Antiviral Agents
  • Carbolines
  • Plant Extracts