Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control

Kathryn B Kirkland; Elizabeth A Talbot; Michael D Decker; Kathryn M Edwards

doi:10.1086/603555

Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control

Clin Infect Dis. 2009 Aug 15;49(4):584-7. doi: 10.1086/603555.

Authors

Kathryn B Kirkland¹, Elizabeth A Talbot, Michael D Decker, Kathryn M Edwards

Affiliation

¹ Department of Medicine, Section of Infectious Disease and International Health, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. [email protected]

PMID: 19589084
DOI: 10.1086/603555

Abstract

We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antibodies, Bacterial / blood*
Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology*
Disease Outbreaks / prevention & control*
Female
Health Personnel*
Humans
Immunization, Secondary
Male
Middle Aged
Whooping Cough / epidemiology*
Whooping Cough / prevention & control*
Young Adult

Substances

Antibodies, Bacterial
Diphtheria-Tetanus-acellular Pertussis Vaccines