Life-time adversities, reported thirteen years after a suicide attempt: relationship to recovery, 5HTTLPR genotype, and past and present morbidity

Arch Suicide Res. 2009;13(3):214-29. doi: 10.1080/13811110903044328.

Abstract

In this study, we investigated how adversities related to past and present morbidity, and genotype. Forty-two, suicide attempters and 22 matched control patients were followed-up after 13 years. Life-time adversities were explored in an interview, and the patients were reassessed psychiatrically. The serotonin-transporter-linked promotor region (5-HTTLPR) was typed. More adversities were reported by suicide attempters than controls, and by still-ill than recovered suicide attempters. Adversities reported at follow-up were related to psychiatric morbidity at follow-up, but not to morbidity 13 years earlier. The 5-HTTLPR, genotype was associated with reported adversities, but not chances of recovery. Adversities potentially affected chronic morbidity. 5-HTTLPR genotype did not affect long-term recovery.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Life Change Events*
  • Male
  • Middle Aged
  • Morbidity
  • Outcome Assessment, Health Care / statistics & numerical data
  • Polymorphism, Genetic
  • Psychiatric Status Rating Scales
  • Risk Factors
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Suicide, Attempted / psychology
  • Suicide, Attempted / statistics & numerical data*
  • Surveys and Questionnaires

Substances

  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins