Peduncular hallucinosis: a polysomnographic and spect study of a patient and efficacy of serotonergic therapy

Sleep Med. 2009 Dec;10(10):1158-60. doi: 10.1016/j.sleep.2009.05.005. Epub 2009 Jul 9.

Abstract

Peduncular hallucinosis (PH) consists of formed and coloured visual images, which the patient knows are unreal; it is often associated with lesions of the pons, midbrain and diencephalon. A 72-year-old man had noted the sudden onset of visual hallucinations one year before, specifying the time and body position in a 4-week, 24-h diary. Thereafter, he underwent video-polysomnography (VPSG), brain magnetic resonance imaging (MRI), angiography (MRA), proton spectroscopy ((1)H MRS), and single photon emission tomography (SPECT). Patient's diaries and VPSG showed a strong clustering of hallucinatory experiences during the evening/night time while lying in supine position, similar to hypnagogic hallucination and sleep paralysis in supine position. Repeated episodes of REM sleep behaviour disorder (RBD) occurred during the night. MRI and MRA showed an elongated and dilated left internal carotid artery displacing the left subthalamus upwards, and (1)H MRS relatively decreased N-acetyl-aspartate in the left subthalamus. Brain SPECT during PH revealed hypoperfusion in the right temporal region and hyperperfusion in the left occipital and right opercular regions (the latter possibly related to the patient's awareness of unreality). PH resolved with serotonergic (citalopram) therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Awareness / physiology
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy
  • Brain Ischemia / physiopathology
  • Carotid Artery Diseases / complications
  • Carotid Artery Diseases / diagnosis
  • Carotid Artery Diseases / physiopathology
  • Carotid Artery, Internal
  • Citalopram / therapeutic use*
  • Dilatation, Pathologic
  • Dominance, Cerebral / physiology
  • Frontal Lobe / blood supply
  • Hallucinations / diagnosis*
  • Hallucinations / drug therapy*
  • Hallucinations / physiopathology
  • Humans
  • Magnetic Resonance Angiography / drug effects
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Male
  • Occipital Lobe / blood supply
  • Polysomnography* / drug effects
  • REM Sleep Behavior Disorder / diagnosis*
  • REM Sleep Behavior Disorder / drug therapy*
  • REM Sleep Behavior Disorder / physiopathology
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Subthalamus / physiopathology
  • Tegmentum Mesencephali / drug effects
  • Tegmentum Mesencephali / physiopathology*
  • Temporal Lobe / blood supply
  • Tomography, Emission-Computed, Single-Photon*
  • Video Recording*

Substances

  • Serotonin Uptake Inhibitors
  • Citalopram