Abstract
Tyrianthins A (1) and B (2), two new partially acylated glycolipid ester-type heterodimers were isolated from Ipomoea tyrianthina. Scammonic acid A was determined as the glycosidic acid in both monomeric units. Tyrianthin A (1) (IC(50) 0.24+/-0.09 microM and E(max) 81.80+/-0.98%), and tyrianthin B (2) (IC(50) 0.14+/-0.08 microM and E(max) 87.68+/-0.72%) showed significant in vitro relaxant effect on aortic rat rings, in endothelium- and concentration-dependent manners. Also, these compounds were able to increase the release of GABA and glutamic acid in brain cortex, and displayed weak antimycobacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification
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Antitubercular Agents / pharmacology
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Dimerization
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Glutamic Acid / metabolism
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Glycolipids / chemistry*
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Glycolipids / isolation & purification
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Glycolipids / pharmacology
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Ipomoea / chemistry*
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Mice
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Plant Roots / chemistry
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Rats
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Vasodilator Agents / chemistry*
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Vasodilator Agents / isolation & purification
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Vasodilator Agents / pharmacology
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gamma-Aminobutyric Acid / metabolism
Substances
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Antitubercular Agents
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Glycolipids
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Vasodilator Agents
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tyrianthin A
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tyrianthin B
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Glutamic Acid
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gamma-Aminobutyric Acid