[Study on radiation sensitivity of colorectal cancer cells using gene expression profile]

Xiao-dong Yang; Chun-gen Xing; Wei Gong; Li-ying Zhou; Yong-you Wu; Kui Zhao

[Study on radiation sensitivity of colorectal cancer cells using gene expression profile]

Zhonghua Wei Chang Wai Ke Za Zhi. 2009 Jul;12(4):371-3.

[Article in Chinese]

Authors

Xiao-dong Yang¹, Chun-gen Xing, Wei Gong, Li-ying Zhou, Yong-you Wu, Kui Zhao

Affiliation

¹ Department of General Surgery, The Second Affiliated Hospital, Suzhou University, Suzhou 215004, China.

PMID: 19598022

Abstract

Objective: To screen the radiosensitivity-related genes of colorectal cancer cells.

Methods: Gene expression profiles of two different radiosensitivity cells(colorectal cancer cell line Lovo and SW480) were obtained by cDNA array and the differences of gene expression profiles between the two cells were analyzed.

Results: Genes of more than 2-fold expressive differentiation were screened. In Lovo cells, 908 up-regulated genes were found, including higher expression genes CEACAM5, THBS1, SERPINE2, ARL7, HPGD, while 1312 genes were down-regulated. In SW480 cells, higher expression genes were SCD, NQ01, LYZ, KRT20 and ATP1B1.

Conclusion: Gene profiles can reflect the radiosensitivity of colorectal cancer cells, which will provide the choice for the further study of radiosensitivity in colorectal cancer.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Colorectal Neoplasms / genetics*
Gene Expression
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic
Genome, Human
Humans
Oligonucleotide Array Sequence Analysis
Radiation Tolerance / genetics*