Abstract
Here it is reported the virological dynamic of HBV and HCV, identified in the plasma, peripheral blood mononuclear cells and tissue liver, in a patient with chronic HBV-HCV coinfection. A treatment with pegylated Interferon plus Ribavirin determined a sustained virological response for HCV in all the three studied compartments, but a reactivation of chronic HBV infection was observed. In fact, while at the first observation HBV-DNA was detectable only in the liver tissue, after antiviral therapy it was detectable in all the three compartments; moreover this HBV reactivation was associated with a hepatic flare. Then, the patient was treated with Entecavir, which has been determining the clearance of HBV from the peripheral compartments (plasma and PBMC) until today.
MeSH terms
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Adult
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Antiviral Agents / administration & dosage
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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DNA, Viral / blood
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Drug Therapy, Combination
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Follow-Up Studies
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Hepatitis B Antibodies / blood
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Hepatitis B Antigens / blood
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Hepatitis B, Chronic / blood
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Hepatitis B, Chronic / complications
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Hepatitis B, Chronic / drug therapy
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Hepatitis B, Chronic / pathology
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Hepatitis B, Chronic / virology*
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Hepatitis C Antibodies / blood
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Hepatitis C, Chronic / blood
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / drug therapy
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Hepatitis C, Chronic / pathology
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Hepatitis C, Chronic / virology*
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Humans
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Interferon alpha-2
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Interferon-alpha / administration & dosage
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Interferon-alpha / pharmacology*
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Interferon-alpha / therapeutic use
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Leukocytes, Mononuclear / virology
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Liver / pathology
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Liver / virology
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Liver Cirrhosis / etiology
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Liver Cirrhosis / pathology
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Liver Cirrhosis / virology
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Male
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RNA, Viral / blood
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Recombinant Proteins
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Ribavirin / administration & dosage
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Ribavirin / pharmacology*
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Ribavirin / therapeutic use
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Viral Load
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Viremia / blood
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Viremia / complications
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Viremia / drug therapy
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Viremia / pathology
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Viremia / virology*
Substances
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Antiviral Agents
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DNA, Viral
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Hepatitis B Antibodies
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Hepatitis B Antigens
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Hepatitis C Antibodies
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Interferon alpha-2
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Interferon-alpha
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RNA, Viral
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Recombinant Proteins
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Ribavirin