Abstract
We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Death / drug effects
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Cell Line
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Drug Evaluation, Preclinical / methods
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HIV-1 / drug effects*
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HIV-1 / genetics
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HIV-1 / physiology
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Histone Deacetylase Inhibitors
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Histone Deacetylases / metabolism
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Humans
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Hydroxamic Acids / pharmacology*
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Sulfonamides / pharmacology*
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T-Lymphocytes / virology*
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Transcriptional Activation / drug effects*
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Virus Latency / drug effects
Substances
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Histone Deacetylase Inhibitors
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Hydroxamic Acids
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Sulfonamides
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metacept-1
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oxamflatin
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Histone Deacetylases