Does fetal fibronectin testing change patient management in women at risk of preterm labour?

Eur J Obstet Gynecol Reprod Biol. 2009 Oct;146(2):180-3. doi: 10.1016/j.ejogrb.2009.06.021. Epub 2009 Jul 19.

Abstract

Objective: To determine clinicians' indications for, and actions following, fetal fibronectin testing in both symptomatic and asymptomatic women between 23(+0) and 34(+6) weeks' gestation.

Study design: Following clinician education of the predictive ability of fetal fibronectin testing, results of all fetal fibronectin tests done at St Thomas' Hospital over a 6-week period were analysed. Clinicians were asked if the result changed management and if a reciprocal result would have altered management.

Results: Ninety-seven fetal fibronectin tests were conducted of which 21 (22%) were positive. Follow-up was done for 91 tests of which 25 (28%) test results directly changed management; 81 (89%) test results had the potential to change management independent of the test result.

Conclusion: The results of fetal fibronectin testing directly influenced management in a significant number of patients. A large number of women were asymptomatic at testing. Fetal fibronectin testing could be offered more widely and has the potential to benefit patient management.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / metabolism
  • Diagnostic Tests, Routine
  • Female
  • Fetus / metabolism*
  • Fibronectins / metabolism*
  • Follow-Up Studies
  • Humans
  • Obstetric Labor, Premature / epidemiology*
  • Patient Care Management / trends*
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Trimester, Second / metabolism
  • Pregnancy Trimester, Third / metabolism
  • Reproducibility of Results
  • Risk Factors
  • Sensitivity and Specificity

Substances

  • Biomarkers
  • Fibronectins