Lack of macrolide resistance in Chlamydia trachomatis after mass azithromycin distributions for trachoma

Emerg Infect Dis. 2009 Jul;15(7):1088-90. doi: 10.3201/eid1507.081563.

Abstract

We investigated antimicrobial drug resistance in ocular Chlamydia trachomatis 18 months after 4 biannual communitywide distributions of antimicrobial drugs in a region of Ethiopia where ocular strains of C. trachomatis are highly endemic. We found no significant differences in susceptibilities to azithromycin and doxycycline in 6 posttreatment and 4 pretreatment samples.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / therapeutic use*
  • Child
  • Child, Preschool
  • Chlamydia trachomatis / drug effects*
  • Chlamydia trachomatis / genetics
  • Cycloheximide / pharmacology
  • Drug Resistance, Microbial / genetics*
  • Ethiopia / epidemiology
  • Eye Diseases / drug therapy
  • Eye Diseases / epidemiology
  • Eye Diseases / microbiology*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Male
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Prevalence

Substances

  • Anti-Bacterial Agents
  • Azithromycin
  • Cycloheximide