IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis

J Assist Reprod Genet. 2009 May;26(5):273-83. doi: 10.1007/s10815-009-9328-4. Epub 2009 Jul 24.

Abstract

Purpose: To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.

Methods: Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.

Results: Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.

Conclusions: In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Abortion, Spontaneous
  • Adult
  • Aneuploidy*
  • Female
  • Fertilization in Vitro / methods*
  • Genetic Diseases, Inborn / diagnosis*
  • Genetic Diseases, Inborn / genetics*
  • Humans
  • Male
  • Maternal Age
  • Pregnancy
  • Preimplantation Diagnosis / methods*
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Sperm Injections, Intracytoplasmic / methods*
  • Treatment Outcome